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生理生化組

基本資料表

劉儼毅
04-7232105-3462
current788@cc.ncue.edu.tw
劉儼毅

教師

生理生化組(生物技術碩士班)
助理教授
Bio-403 生物智慧計算 實驗室 主持人:劉儼毅老師
遺傳學及實驗、分子生物學、環境微生物學、人工智慧生物學概論、機器與深度學習概論、通用資料分析
生物資訊技術、omics資料分析、細菌基因體及演化分析、細菌抗藥性大數據分析、流行病學
年度論文名稱
2026Yen-Yi Liu, Li-Wen Huang, Mei-Fang Su, Bo-Ren Chen, Chih-Chieh Chen,Global integrative analysis of whole-genome-based predictions of antimicrobial resistance trends in five major nosocomial pathogens,Microbiology Spectrum,e0013026,(SCI)
2025Yen-Yi Liu, Chi-Ching Lee, Pei-Hsuan Li, Sung-Huan Yu, Mien-Chie Hung, Hsin-Mien Hsu, Chih-Chao Yang, Chen-Chieh Huang, Pei-Yao Kuo, Yi-Chuan Li.,AlphaPPIweb: an integration platform for protein-protein interaction prediction and evaluation,American Journal of Cancer Research,15,3980-3989,(SCI)
2023Yen-Yi Liu, Chu-Yi Hsu, Ya-Chu Yang, Chien-Hsun Huang, Chih-Chieh Chen ,ProbioMinServer: an integrated platform for assessing the safety and functional properties of potential probiotic strains ,Bioinformatics Advances ,3,vbad153,(其他)
2023Chen-Shiou Wu, Yi-Chuan Li, Shin-Lei Peng, Chung-Yu Chen, Hsiao-Fan Chen, Po-Ren Hsueh, Wei-Jan Wang,Coffee as a dietary strategy to prevent SARS-CoV-2 infection ,Cell & Bioscience ,13,(SCI)
2022Wei-Jan Wang, Yeh Chen, Wen-Chi Su, Yen-Yi Liu （co-first author）, Wan-Jou Shen, Wei-Chao Chang, Shen,Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2,Journal of Food Biochemistry,(SCI)
2022Chih-Chieh Chen, Yen-Yi Liu, Ya-Chu Yang, Chu-Yi Hsu,5NosoAE: a web server for nosocomial bacterial antibiogram investigation and epidemiology survey,Nucleic Acids Research,50,(SCI)
2022Yen-Yi Liu, Chih-Chieh Chen, Chien-Hua Yang, Hui-Yi Hsieh, Jia-Xin He, Hao-Hsuan Lin, Chi-Ching Lee,LmTraceMap: A Listeria monocytogenes fast-tracing platform for global surveillance,PloS one,17,(SCI)
2022Yi-Syong Chen, Yueh-Hua Tu, Bo-Han Chen, Yen-Yi Liu, Yu-Ping Hong, Ru-Hsiou Teng, You-Wun Wang, Chie,cgMLST@ Taiwan: a web service platform for Vibrio cholerae cgMLST profiling and global strain tracking,Journal of Microbiology, Immunology and Infection,55,102~106,(SCI)
2022Yi-Chuan Li, Hirohito Yamaguchi, Yen-Yi Liu, Kai-Cheng Hsu, Ting-Hsuan Sun, Pei-Chi Sun, Mien-Chie H,Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1,American Journal of Cancer Research,(SCI)
2022Chih-Hao Lu, Chih-Chieh Chen, Chin-Sheng Yu, Yen-Yi Liu, Jia-Jun Liu, Sung-Tai Wei, Yu-Feng Lin ,MIB2: Metal ion-binding site prediction and modeling server,Bioinformatics ,38,4428-4429,(SCI)
2022Hsiao-Fan Chen*, Po-Ren Hsueh*, Yen-Yi Liu*（co-first）, Yeh Chen, Sui-Yuan Chang, Wei-Jan Wang, Chen-,Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2 ,American Journal of Cancer Research ,12,3333-3346,(SCI)
2021Yen-Yi Liu, Chih-Chieh Chen,A machine learning-based typing scheme refinement for Listeria monocytogenes core genome multilocus sequence typing with high discriminatory power for common source outbreak tracking,PloS one,16,(SCI)
2021Yen-Yi Liu, Bo-Han Chen, Chih-Chieh Chen, Chien-Shun Chiou,Assessment of metrics in next-generation sequencing experiments for use in core-genome multilocus sequence type,PeerJ,9,(SCI)
2021Ming-Ko Chiang, Pei-Yi Hsiao, Yen-Yi Liu, Hui-Ling Tang, Chien-Shun Chiou, Min-Chi Lu, Yi-Chyi Lai,Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model,Gut microbes,13,(SCI)
2020Min-Chi Lu, Ying-Tsong Chen, Hui-Ling Tang, Yen-Yi Liu, Bo-Han Chen, You-Wun Wang, Yi-Syong Chen, Ru,Transmission and evolution of OXA-48-producing Klebsiella pneumoniae ST11 in a single hospital in Taiwan,Journal of Antimicrobial Chemotherapy,75,318~326,(SCI)
2019Yueh-Hua Tu, Bo-Han Chen, Yu-Ping Hong, Ying-Shu Liao, Yi-Syong Chen, Yen-Yi Liu, Ru-Hsiou Teng, You,Emergence of Vibrio cholerae O1 sequence type 75 in Taiwan,Emerging infectious diseases,26,164-166,(SCI)
2019Ying-Shu Liao, Bo-Han Chen, Yu-Ping Hong, Ru-Hsiou Teng, You-Wun Wang, Shiu-Yun Liang, Yen-Yi Liu, Y,Emergence of multidrug-resistant Salmonella enterica serovar Goldcoast strains in Taiwan and international spread of the ST358 clone,Antimicrobial agents and chemotherapy,63,(SCI)
2019Ming-Hsin Tsai, Yen-Yi Liu （co-first author）, Chih-Chieh Chen,OutbreakFinder: a visualization tool for rapid detection of bacterial strain clusters based on optimized multidimensional scaling,PeerJ,(SCI)
2019Ming-Hsin Tsai, Yen-Yi Liu （co-first author）, Von-Wun Soo, Chih-Chieh Chen,A new genome-to-genome comparison approach for large-Scale revisiting of current microbial taxonomy,Microorganisms ,7,(SCI)
2019Yen-Yi Liu, Ji-Wei Lin, Chih-Chieh Chen,The Cano-eMLST Program: An Approach for the Calculation of Canonical Extended Multi-Locus Sequence Typing, Making Comparison of Genetic Differences Among Bunches of Bacterial Strains,Microorganisms ,7,(SCI)
2019Yen-Yi Liu, Ji-Wei Lin, Chih-Chieh Chen,cano-wgMLST_BacCompare: a bacterial genome analysis platform for epidemiological investigation and comparative genomic analysis,Frontiers in microbiology,(SCI)
2018Yu-Ping Hong, You-Wun Wang, I-Hsiu Huang, Yu-Chieh Liao, Hung-Chih Kuo, Yen-Yi Liu, Yueh-Hua Tu, Bo-,Genetic relationships among multidrug-resistant Salmonella enterica serovar Typhimurium strains from humans and animals,Antimicrobial agents and chemotherapy,62,(SCI)
2017Yen-Yi Liu, Chih-Chieh Chen,Computational analysis of the molecular mechanism of RamR mutations contributing to antimicrobial resistance in Salmonella enterica,Scientific reports,7,1~9,(SCI)
2017Ming-Hsin Tsai, Yen-Yi Liu （co-first author）, Von-Wun Soo,PathoBacTyper: a web server for pathogenic bacteria identification and molecular genotyping,Frontiers in Microbiology,8,(SCI)
2017Chien-Shun Chiou, Ying-Tsong Chen, You-Wun Wang, Yen-Yi Liu, Hung-Chih Kuo, Yeuh-Hua Tu, Ann-Chi Lin,Dissemination of mcr-1-Carrying Plasmids among Colistin-Resistant Salmonella Strains from Humans and Food-Producing Animals in Taiwan,Antimicrobial agents and chemotherapy,61,(SCI)
2017Ying-Shu Liao, Yen-Yi Liu, Yi-Chun Lo, Chien-Shun Chiou,Azithromycin-nonsusceptible Shigella flexneri 3a in men who have sex with men, Taiwan, 2015–2016,Emerging infectious diseases,23,(SCI)
2016Yen-Yi Liu, Chih-Chieh Chen, Chien-Shun Chiou,Construction of a Pan-Genome Allele Database of Salmonella enterica Serovar Enteritidis for Molecular Subtyping and Disease Cluster Identification,Frontiers in microbiology,7,(SCI)
2016Yen-Yi Liu, Chien-Shun Chiou, Chih-Chieh Chen,PGAdb-builder: a web service tool for creating pan-genome allele database for molecular fine typing,Scientific reports,6,1~5,(SCI)
2015Chien-Shun Chiou, Mia Torpdahl, Ying-Shu Liao, Chun-Hsing Liao, Chi-Sen Tsao, Shiu-Yun Liang, You-Wu,Usefulness of pulsed-field gel electrophoresis profiles for the determination of Salmonella serovars,International journal of food microbiology,214,(SCI)
2015Chien-Shun Chiou, Munirul Alam, Jung-Che Kuo, Yen-Yi Liu, Pei-Jen Wang,Chromosome-mediated multidrug resistance in Salmonella enterica serovar Typhi,Antimicrobial agents and chemotherapy,59,721~723,(SCI)
年度計畫名稱參與人計畫期間補助/委託或合作機構
2026利用泛基因組多位址分型原理及機器學習方法研究台灣重要院感菌種抗藥性傳播模式與視覺化整合分析平台之建置(3/3)劉儼毅2026-08~2027-07國家科學及技術委員會
2025利用泛基因組多位址分型原理及機器學習方法研究台灣重要院感菌種抗藥性傳播模式與視覺化整合分析平台之建置(2/3)劉儼毅2025-08~2026-07國家科學及技術委員會
2024利用泛基因組多位址分型原理及機器學習方法研究台灣重要院感菌種抗藥性傳播模式與視覺化整合分析平台之建置(1/3)劉儼毅2024-08~2025-07國家科學及技術委員會
2024利用泛基因體等位基因比對機器學習方法研究國內重要院內感染病原菌之族群遺傳特性與流行病學分析劉儼毅2024-01~2024-12國立彰化師範大學
2023利用泛基因體等位基因資料庫與機器學習方法建置重要院內感染病原菌之大規模視覺化抗藥譜比對與流行病學分析平台 II劉儼毅2023-08~2024-07國家科學及技術委員會
2022利用泛基因體等位基因資料庫與機器學習方法建置重要院內感染病原菌之大規模視覺化抗藥譜比對與流行病學分析平台劉儼毅2022-08~2023-07國家科學及技術委員會
2021以分子動力學方法研究RamR蛋白與藥物之作用性並篩選具潛力之抑制劑以對抗多重抗藥性細菌劉儼毅2021-10~2022-07中國醫藥大學
2021以泛基因體資料庫為基礎結合機器學習及深度學習方法建置整合性益生菌之基因體比較及功能性預測平台劉儼毅2021-08~2024-07國家科學及技術委員會
學校名稱國別系所學位起迄年月
國立交通大學（陽明交通大學）台灣生物資訊及系統生物研究所博士2008-09~2013-05
服務機關名稱單位職務期間
國立彰化師範大學生物學系助理教授2022-08~
中國醫藥大學公共衛生學系助理教授2020-11~2022-07
衛生福利部疾病管制署檢驗及疫苗研製中心約聘研究人員2019-01~2020-11
國家衛生研究院群體健康科學研究所博士後研究員2016-10~2018-12
衛生福利部疾病管制署檢驗及疫苗研製中心博士後研究員（研發替代役）2013-11~2016-09